反应详情

温度

80 °C

To a mixture of 6 g of the crude product obtained in step 3 and 5.1 g 4-formylphenylboronic acid in 210 mL 1,2-dimethoxyethane were added 0.96 g dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium (II) dichloromethane adduct and 42 mL of a 10% w/w sodium carbonate solution. The resulting mixture was heated to 80° C. under an inert gas atmosphere for 15 h. The work up was performed by diluting the reaction mixture with water and dichloromethane, separating the phases and extraction of the aqueous phase with dichloromethane. The combined organic layers were dried over sodium sulphate and evaporated. The residue was suspended in ethyl acetate and the resulting mixture stirred for 2 h at room temperature. The product was collected by filtration and used without further purification.

1. customseparating
2. extractionthe phases and extraction of the aqueous phase with dichloromethane
3. dry with materialThe combined organic layers were dried over sodium sulphate
4. customevaporated
5. filtrationThe product was collected by filtration
6. customused without further purification