Diethyl phenylmalonate → HCID 178517387, compound

Participants

Reaction Steps

A solution of 10 g 1,2,4-triazol-3-amine and 33.7 g diethyl phenylmalonate in N,N-dibutylbutan-1-amine was stirred at 185° C. over night. The solution was diluted with 10% w/w NaOH solution, the resulting mixture was stirred for 30 min and the organic phase was separated. The aqueous layer was extracted with diethylether, acidified with concentrated HCl until precipitation of the product was complete and the precipitate collected by filtration to yield the product, which was used without further purification.

Provenance & Evidence