Sodium Carbonate → HCID 86630656, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 130 mg 5-chloro-6-phenyl[1,2,4]triazolo[1,5-a]pyrimidine and 93 mg 4-formylphenylboronic acid in 5 mL 1,2-dimethoxyethane was added 1.2 mL of a 10% w/w sodium carbonate solution and 65 mg tetrakis (triphenylphosphine) palladium(0) and the resulting mixture was heated to 90° C. under an inert gas atmosphere for 18 h. The work up was performed by diluting the reaction mixture with water and dichloromethane, separating the phases and extraction of the aqueous phase with dichloromethane. The combined organic layers were dried over sodium sulphate, evaporated and the residue suspended in methanol. The crystalline product was isolated by filtration yielding the desired product. The filtrate was evaporated to dryness, dissolved in ethyl acetate and additional product precipitated by the addition of petrolether.

Provenance & Evidence