反应详情

温度

120 °C

500 mg 4-(6-phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde and 880 mg 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate were dissolved in 25 mL chloroform and heated under microwave irradiation to 120° C. After for 45 min and 4 h additional portions of 200 mg of 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate were added and heating continued at 120° C. The reaction was worked up after 5 h by diluting with water and extraction with dichloromethane. The combined organic layers were dried over Na2SO4 and the solvent evaporated. The crude material was purified on silica gel (dichloromethane/ethyl acetate.

1. temperatureheating
2. customcontinued at 120° C
3. waitThe reaction was worked up after 5 h
4. dry with materialThe combined organic layers were dried over Na2SO4
5. customthe solvent evaporated
6. customThe crude material was purified on silica gel (dichloromethane/ethyl acetate