反应详情

To a mixture of 550 mg of the product of step 1 and 350 mg 4-formylphenylboronic acid in 10 mL 1,2-dimethoxyethane, 55 mg tetrakis (triphenylphosphine) palladium(0) and 4 mL of a 10% w/w sodium carbonate solution were added and the resulting mixture was heated by microwave for 2 h. The work up was performed by diluting the reaction mixture with water and dichloromethane, separating the phases and extraction of the aqueous phase with dichloromethane. The combined organic layers were dried over sodium sulphate and evaporated. The residue was suspended in ethyl acetate and the resulting mixture was stirred for 2 h at room temperature. The product was collected by filtration and used without further purification.

1. additionwere added
2. temperaturethe resulting mixture was heated by microwave for 2 h
3. customseparating
4. extractionthe phases and extraction of the aqueous phase with dichloromethane
5. dry with materialThe combined organic layers were dried over sodium sulphate
6. customevaporated
7. filtrationThe product was collected by filtration
8. customused without further purification