反应详情

0.2 g (0.64 mmol) 4-(2-Methyl-6-phenyl-imidazo[1,2-a]pyrimidin-7-yl)benzaldehyde, described in intermediate example 15.1, are dissolved in 2.8 mL chloroform and treated with 170 mg (0.96 mmol) N-bromosuccinimide. The mixture is heated for 2.5 hours at reflux. The solvent is removed and the residue purified by chromatography (silicagel, dichloromethane/methanol). 198.4 mg (75.3%) of the desired compound are obtained.

1. temperatureThe mixture is heated for 2.5 hours
2. temperatureat reflux
3. customThe solvent is removed
4. customthe residue purified by chromatography (silicagel, dichloromethane/methanol)