Diethyl phenylmalonate → HCID 178517335, compound

Participants

Reaction Steps

A solution of 9 g 3-amino pyrazole and 25.6 g diethyl phenylmalonate in N,N-dibutylbutan-1-amine was stirred at 185° C. over night. The reaction mixture consisted of two layers after cooling to room temperature. The top layer was removed and the lower layer was diluted with dichloromethane and methanol. The resulting solution was concentrated and extracted with a mixture of diethyl ether and 10% w/w NaOH solution. The organic layer was discarded and aqueous layer acidified with concentrated HCl. The precipitated product was collected by filtration.

Provenance & Evidence