反应详情

温度

120 °C

To a mixture of 220 mg of the product obtained in step 2 and 131 mg 4-formylphenylboronic acid in 10 mL 1,2-dimethoxyethane were added 25 mg dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium (II) dichloromethane adduct and 7 mL of a 10% w/w sodium carbonate solution and the resulting mixture was heated to 120° C. by microwave irradiation under an inert gas atmosphere for 1 h. The work up was performed by diluting the reaction mixture with water and dichloromethane, separating the phases and extraction of the aqueous phase with dichloromethane. The combined organic layers were dried over sodium sulphate and evaporated. The crude product was purified by silica gel chromatography (dichloromethane/methanol).

1. customseparating
2. extractionthe phases and extraction of the aqueous phase with dichloromethane
3. dry with materialThe combined organic layers were dried over sodium sulphate
4. customevaporated
5. customThe crude product was purified by silica gel chromatography (dichloromethane/methanol)