Dimethylacetamide → HCID 86630676, compound

Participants

Reaction Conditions

Reaction Steps

400 mg 4-(3-bromo-6-phenylpyrazolo[1,5-a]pyrimidin-5-yl)benzaldehyde (prepared as described above), 7.0 mg zinc powder, 75.0 mg Zn(CN)2 and 39.0 mg dichloride[1,1′-bis(diphenylphosphino)ferrocene]palladium (II) dichloromethane adduct were suspended in 10 mL dimethylacetamide and the mixture was heated for 45 min under microwave irradiation to 160° C. The workup was performed by diluting the mixture with water and dichloromethane, extracting the aqueous layer twice and drying the combined organic layers over Na2SO4. The compound was isolated by evaporation of the solvent and chromatography on silica gel (dichloromethane/ethyl acetate).

Provenance & Evidence