Potassium Phosphate, Tribasic → HCID 86630682, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 0.50 g 4-(3-bromo-6-phenylpyrazolo[1,5-a]pyrimidin-5-yl)benzaldehyde (prepared as described under intermediate example 23) and 0.12 g methylboronic acid in 17 mL toluene were added 0.83 g potassium phosphate tribasic, 0.029 g palladium acetate and 0.11 g S-PHOS. The reaction mixture was heated for 1 h under microwave irradiation to 120° C. This mixture was worked up by diluting with water and extraction with dichloromethane. The organic layers were dried over Na2SO4 and concentrated to yield the crude product, which was purified by chromatography on silica gel (ethyl acetate/dichloromethane).

Provenance & Evidence