Ammonia → HCID 86630685, compound

Participants

Reaction Steps

6.00 g 5,7-dichloro-2-ethyl-6-phenyl[1,2,4]triazolo[1,5-a]pyrimidine was dissolved in 180 mL dichloromethane. 180 mL saturated brine, 120 mL ammonia solution 25% w/w and 6.00 g zinc powder were added and the mixture was stirred at room temperature for 3 h. The reaction mixture was filtered through Celite and was washed with dichloromethane and water. The organic phase was separated and the water phase was extracted with dichloromethane. The combined organic layers were dried over Na2SO4 and the solvent was evaporated. The residue contained 2-ethyl-6-phenyl[1,2,4]triazolo[1,5-a]pyrimidine. This mixture was used without further purification for the next reaction.

Provenance & Evidence