Sodium Carbonate → HCID 86630687, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 3.90 g of the crude product obtained in step 3 and 3.00 g 4-formylphenylboronic acid in 180 mL 1,2-dimethoxyethane were added 0.55 g dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium (II) and 25 mL of a 10% w/w sodium carbonate solution. The resulting mixture was heated to 90° C. under an inert gas atmosphere for 20 h. The work up was performed by diluting the reaction mixture with water and dichloromethane, separating the phases and extraction of the aqueous phase with dichloromethane. The combined organic layers were dried over sodium sulphate, the solvent was evaporated and the residue was suspended in ethyl acetate. The crude product was isolated by filtration, which was purified on silica gel (dichloromethane/methanol).

Provenance & Evidence