Trimethyl((tributylstannyl)ethynyl)silane → HCID 86630695, compound

Participants

Reaction Steps

300 mg 4-(2-bromo-6-phenyl[1,2,4]triazolo[1,5-a]pyrimidin-5-yl)benzaldehyde (prepared as described above), 613 mg trimethyl[(tributylstannyl)ethynyl]silane and 46 mg Pd(PPh3)4 were suspended in 12 mL toluene under a nitrogen atmosphere. The mixture was heated (microwave irradiation) to 120° C. for 1 h. This mixture was worked up by diluting with water and extraction with dichloromethane. The organic layers were dried over Na2SO4 and concentrated to yield the crude product, which was purified by chromatography on silica gel (ethyl acetate/dichloromethane).

Provenance & Evidence