Methylamine → HCID 86703042, compound

Participants

Reaction Conditions

Reaction Steps

1 g (2.9 mmol) 5,7-dichloro-6-phenyl-2-pyridine-2-yl-[1,2,4]triazolo[1,5-a]pyrimidine are given in 8.2 mL DMF (no complete dissolution). After addition of 3.65 mL of a 2M (7.3 mmol) solution of methylamine in THF the reaction mixture is heated in a microwave oven at 100° C. for 20 minutes. From the clear brown solution the DMF is evaporated, the residue is diluted with brine and extracted three times with dichloromethane. The combined organic extracts are dried over Na2SO4 and the solvent is evaporated and the residue purified by chromatography (silicagel, eluents: dichloromethane, methanol). 265 mg (26.9%) of the desired product are obtained.

Provenance & Evidence