Acetic Acid → HCID 178432368, compound

Participants

Reaction Steps

77 mg (0.38 mmol) 2-(5-azetidine-3-yl-[1,2,4]triazol-3-yl)-pyridine hydrochloride salt was dissolved in 6 mL methanol and 0.1 mL triethylamine. After addition of 100 mg (0.31 mmol) 4-(2-methyl-6-phenyl[1,2,4]triazolo[1,5-a]pyrimidin-5-yl)benzaldehyde dissolved in 6 mL DMF, 0.06 mL acetic acid and 131 mg (0.76 mmol) NaBH(OAc)3 the reaction mixture was stirred at room temperature. Three additional portions of 2 equivalents NaBH(OAc)3 each were added after 2, 4 and 6 hours. The solvent was removed by evaporation and the residue was purified by chromatography on silica gel (dichloromethane/methanol) to yield 42 mg of the desired product.

Provenance & Evidence