2-(5-Azetidine-3-yl-[1,2,4]triazol-3-yl)-pyridine hydrochloride salt → HCID 178505975, compound

HRID 1851256Notes

Reaction equation

HRID 1851256 reaction equation
[F:1][C:2]1[N:6]2[CH:7]=[C:8]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:9]([C:11]3[CH:18]=[CH:17][C:14]([CH:15]=O)=[CH:13][CH:12]=3)=[N:10][C:5]2=[N:4][CH:3]=1.Cl.[NH:26]1[CH2:29][CH:28]([C:30]2[NH:34][N:33]=[C:32]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][N:36]=3)[N:31]=2)[CH2:27]1>>[F:1][C:2]1[N:6]2[CH:7]=[C:8]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:9]([C:11]3[CH:18]=[CH:17][C:14]([CH2:15][N:26]4[CH2:27][CH:28]([C:30]5[N:31]=[C:32]([C:35]6[CH:40]=[CH:39][CH:38]=[CH:37][N:36]=6)[NH:33][N:34]=5)[CH2:29]4)=[CH:13][CH:12]=3)=[N:10][C:5]2=[N:4][CH:3]=1

Participants

3

Reactant 2

HCID 687522832-(5-Azetidine-3-yl-[1,2,4]triazol-3-yl)-pyridine hydrochloride saltHCID 866306594-(3-Fluoro-6-phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde

Product 1

HCID 178505975HCID 178505975, compoundYield 57.6%

Procedure

This compound was prepared in analogy by reacting 90 mg (0.28 mmol) 4-(3-fluoro-6-phenyl-imidazo[1,2-a]pyrimidin-7-yl)-benzaldehyde with 93 mg (0.34 mmol) 2-(5-azetidine-3-yl-[1,2,4]triazol-3-yl)-pyridine hydrochloride salt according to the procedure in example 1. After four and a half hours the reaction mixture was worked up and purified in the usual way as described in example 1. 81 mg of the desired product were obtained.

Workup

  1. customThis compound was prepared in analogy
  2. waitAfter four and a half hours the reaction mixture was worked up
  3. custompurified in the usual way

Sources & evidence

ORD record
ord-4b171b676b314596840d16651b3db474
Source dataset
uspto-grants-2015_02
Patent number
US08957064B2

Reaction notes

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