2-(5-Azetidine-3-yl-[1,2,4]triazol-3-yl)-pyridine hydrochloride salt → HCID 178478263, compound

HRID 1851257Notes

Reaction equation

HRID 1851257 reaction equation
[Cl:1][C:2]1[N:6]2[CH:7]=[C:8]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:9]([C:11]3[CH:18]=[CH:17][C:14]([CH:15]=O)=[CH:13][CH:12]=3)=[N:10][C:5]2=[N:4][CH:3]=1.Cl.[NH:26]1[CH2:29][CH:28]([C:30]2[NH:34][N:33]=[C:32]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][N:36]=3)[N:31]=2)[CH2:27]1>>[Cl:1][C:2]1[N:6]2[CH:7]=[C:8]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:9]([C:11]3[CH:18]=[CH:17][C:14]([CH2:15][N:26]4[CH2:27][CH:28]([C:30]5[N:31]=[C:32]([C:35]6[CH:40]=[CH:39][CH:38]=[CH:37][N:36]=6)[NH:33][N:34]=5)[CH2:29]4)=[CH:13][CH:12]=3)=[N:10][C:5]2=[N:4][CH:3]=1

Participants

3

Reactant 2

HCID 687522832-(5-Azetidine-3-yl-[1,2,4]triazol-3-yl)-pyridine hydrochloride saltHCID 867030314-(3-Chloro-6-phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde

Product 1

HCID 178478263HCID 178478263, compoundYield 52%

Procedure

200 mg (0.6 mmol) 4-(3-chloro-6-phenyl-imidazo[1,2-a]pyrimidin-7-yl)benzaldehyde was reacted with 197 mg (0.72 mmol) 2-(5-azetidine-3-yl-[1,2,4]triazol-3-yl)-pyridine hydrochloride salt according to the procedure in example 1. After four and a half hours the reaction mixture was worked up and purified in the usual way as described in example 1. 162 mg of the desired product were obtained

Workup

  1. waitAfter four and a half hours the reaction mixture was worked up
  2. custompurified in the usual way

Sources & evidence

ORD record
ord-7b93f7db50ed499ca6584dffa99ba29b
Source dataset
uspto-grants-2015_02
Patent number
US08957064B2

Reaction notes

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