2-(Piperidin-4-yl)quinoxaline → 2-{1-[4-(6-Phenyl-imidazo[1,2-a]pyrimidin-7-yl)-benzyl]-piperidine-4-yl}-quinoxaline

HRID 1851262Notes

Reaction equation

HRID 1851262 reaction equation
[C:1]1([C:7]2[C:8]([C:16]3[CH:23]=[CH:22][C:19]([CH:20]=O)=[CH:18][CH:17]=3)=[N:9][C:10]3[N:11]([CH:13]=[CH:14][N:15]=3)[CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:24]1[CH2:29][CH2:28][CH:27]([C:30]2[CH:39]=[N:38][C:37]3[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=3)[N:31]=2)[CH2:26][CH2:25]1>>[C:1]1([C:7]2[C:8]([C:16]3[CH:23]=[CH:22][C:19]([CH2:20][N:24]4[CH2:25][CH2:26][CH:27]([C:30]5[CH:39]=[N:38][C:37]6[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=6)[N:31]=5)[CH2:28][CH2:29]4)=[CH:18][CH:17]=3)=[N:9][C:10]3[N:11]([CH:13]=[CH:14][N:15]=3)[CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 211980262-(Piperidin-4-yl)quinoxalineHCID 866306554-(6-Phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde

Product 1

HCID 687517372-{1-[4-(6-Phenyl-imidazo[1,2-a]pyrimidin-7-yl)-benzyl]-piperidine-4-yl}-quinoxalineYield 33.2%

Procedure

160 mg (0.53 mmol) 4-(6-phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde and 182 mg (0.64 mmol) 2-piperidine-4-yl-quinoxaline were reacted for two days at room temperature and purified as described in example 6.0. 87.3 mg of the desired compound were obtained.

Workup

  1. custompurified

Sources & evidence

ORD record
ord-56196640d83f458796e3f105b4258778
Source dataset
uspto-grants-2015_02
Patent number
US08957064B2

Reaction notes

Loading…