Triethylamine → HCID 178432370, compound

Participants

Reaction Steps

A mixture of 4-(2-methyl-6-phenyl[1,2,4]triazolo[1,5-a]pyrimidin-5-yl)benzaldehyde (300 mg, 0.95 mmol), 2-(5-pyrrolidin-3-yl-2H-[1,2,4]triazol-3-yl)-pyridine hydrochloride salt (358 mg), triethylamine (0.32 mL) and AcOH (0.098 mL) in NMP (8.1 mL) was stirred overnight at room temperature. Sodium triacetoxyborohydride (222 mg) was added and the mixture stirred for 4 h. The mixture was diluted with water, filtered and the filtrate concentrated in vacuo. The residue was co-distilled with toluene and to give the crude product which was purified by preparative HPLC to give the title compound (50 mg).

Provenance & Evidence