2-(Piperidin-4-yl)quinoxaline → 2-(1-{4-[6-(4-Fluorophenyl)-imidazo[1,2-a]pyrimidin-7-yl]-benzyl}-piperidine-4-yl)-quinoxaline

HRID 1851282Notes

Reaction equation

HRID 1851282 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[CH:16]=[N:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[N:8]=2)[CH2:3][CH2:2]1.[F:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[C:25]([C:33]3[CH:40]=[CH:39][C:36]([CH:37]=O)=[CH:35][CH:34]=3)=[N:26][C:27]3[N:28]([CH:30]=[CH:31][N:32]=3)[CH:29]=2)=[CH:20][CH:19]=1>>[F:17][C:18]1[CH:19]=[CH:20][C:21]([C:24]2[C:25]([C:33]3[CH:40]=[CH:39][C:36]([CH2:37][N:1]4[CH2:2][CH2:3][CH:4]([C:7]5[CH:16]=[N:15][C:14]6[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=6)[N:8]=5)[CH2:5][CH2:6]4)=[CH:35][CH:34]=3)=[N:26][C:27]3[N:28]([CH:30]=[CH:31][N:32]=3)[CH:29]=2)=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 211980262-(Piperidin-4-yl)quinoxalineHCID 867030204-[6-(4-Fluorophenyl)imidazo[1,2-a]pyrimidin-7-yl]-benzaldehyde

Product 1

HCID 687532062-(1-{4-[6-(4-Fluorophenyl)-imidazo[1,2-a]pyrimidin-7-yl]-benzyl}-piperidine-4-yl)-quinoxaline

Procedure

The compound is prepared in analogy to example 33.0. 216 mg (0.756 mmol) 2-Piperidine-4-ylquinoxaline are reacted with 200 mg (0.63 mmol) 4-[6-(4-fluorophenyl)-imidazo[1,2-a]pyrimidin-7-yl]-benzaldehyde. After the usual work-up and purification 201 mg (58.9%) of the title compound are obtained.

Workup

  1. customThe compound is prepared in analogy to example 33.0
  2. customAfter the usual work-up and purification 201 mg (58.9%) of the title compound
  3. customare obtained

Sources & evidence

ORD record
ord-10b308f7e25c4ee7b87c81629f48adc5
Source dataset
uspto-grants-2015_02
Patent number
US08957064B2

Reaction notes

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