2-(5-Azetidine-3-yl-[1,2,4]triazole-3-yl)-6-methylpyridine → HCID 178424649, compound

HRID 1851286Notes

Reaction equation

HRID 1851286 reaction equation
[NH:1]1[CH2:4][CH:3]([C:5]2[NH:9][N:8]=[C:7]([C:10]3[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[N:11]=3)[N:6]=2)[CH2:2]1.[CH3:17][C:18]1[N:19]=[C:20]2[N:25]=[C:24]([C:26]3[CH:33]=[CH:32][C:29]([CH:30]=O)=[CH:28][CH:27]=3)[C:23]([C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)=[CH:22][N:21]2[CH:40]=1>>[CH3:17][C:18]1[N:19]=[C:20]2[N:25]=[C:24]([C:26]3[CH:27]=[CH:28][C:29]([CH2:30][N:1]4[CH2:4][CH:3]([C:5]5[N:6]=[C:7]([C:10]6[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[N:11]=6)[NH:8][N:9]=5)[CH2:2]4)=[CH:32][CH:33]=3)[C:23]([C:34]3[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=3)=[CH:22][N:21]2[CH:40]=1

Participants

3

Reactant 2

HCID 687534852-(5-Azetidine-3-yl-[1,2,4]triazole-3-yl)-6-methylpyridineHCID 867030344-(2-Methyl-6-phenyl-imidazo[1,2-a]pyrimidin-7-yl)benzaldehyde

Product 1

HCID 178424649HCID 178424649, compound

Procedure

The compound is prepared in analogy to example 37.0. 306 mg 2-(5-Azetidine-3-yl-[1,2,4]triazole-3-yl)-6-methylpyridine×2HCl (60% pure) are reacted with 200 mg (0.64 mmol) 4-(2-methyl-6-phenyl-imidazo[1,2-a]pyrimidin-7-yl)-benzaldehyde. After the usual work-up and purification 146 mg (42.6%) of the title compound are obtained.

Workup

  1. customThe compound is prepared in analogy to example 37.0
  2. customAfter the usual work-up and purification 146 mg (42.6%) of the title compound
  3. customare obtained

Sources & evidence

ORD record
ord-9ca286e3a1b84baaadd705441358a633
Source dataset
uspto-grants-2015_02
Patent number
US08957064B2

Reaction notes

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