反应详情

133 mg (0.24 mmol) 6-(4-fluorophenyl)-7-(4-{4-[5-(6-methylpyridine-2-yl)-1H-[1,2,4]triazole-3-yl]-piperidine-1-ylmethyl}-phenyl)-imidazo[1,2-a]pyrimidine are dissolved in 2.5 mL chloroform. After addition of 65.2 mg (0.37 mmol) N-bromosuccinimide the reaction mixture is heated for three hours at reflux. The solvent is evaporated and the residue purified by chromatography on silicagel (eluents: dichloromethane/methanol) yielding 97.5 mg (60.8%) of the desired product.

1. temperatureis heated for three hours
2. temperatureat reflux
3. customThe solvent is evaporated
4. customthe residue purified by chromatography on silicagel (eluents: dichloromethane/methanol)