HRID1851304

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID67184

1-Bromopyrrolidine-2,5-dione

C4H4BrNO2

结构：Cc1cccc(-c2nc(C3CN(Cc4ccc(-c5nc6nc(C)cn6cc5-c5ccccc5)cc4)C3)n[nH]2)n1

HCID178424649

未命名化合物

PRODUCTS

生成物

结构：Cc1cccc(-c2nc(C3CN(Cc4ccc(-c5nc6nc(C)c(Br)n6cc5-c5ccccc5)cc4)C3)n[nH]2)n1

HCID178424647

未命名化合物

收率 32.9%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6212

Chloroform

CHCl3

PROCEDURE

实验过程

50 mg (0.098 mmol) 2-Methyl-7-{4-{3-[5-(6-methylpyridine-2-yl)-1H-[1,2,4]triazole-3-yl)-azetidine-1-ylmethyl]-phenyl}-6-phenyl-imidazo[1,2-a]pyrimidine are dissolved in 3.9 mL chloroform. 19.1 mg (0.11 mmol) N-bromosuccinimide are added and the reaction mixture is heated for one hour at reflux. The solvent is evaporated and the residue is purified by chromatography (silicagel, eluents: dichloromethane/methanol). 19.1 mg (31.5%) of the desired compound are obtained.

WORKUP

后处理

temperaturethe reaction mixture is heated for one hour
temperatureat reflux
customThe solvent is evaporated
customthe residue is purified by chromatography (silicagel, eluents: dichloromethane/methanol)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-cad631b7660e4e08a739e7f6003abfd6
来源数据集: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08957064B2
来源说明: uspto-grants-2015_02

反应 SMILES

[CH3:1][C:2]1[N:3]=[C:4]2[N:9]=[C:8]([C:10]3[CH:15]=[CH:14][C:13]([CH2:16][N:17]4[CH2:20][CH:19]([C:21]5[N:25]=[C:24]([C:26]6[CH:31]=[CH:30][CH:29]=[C:28]([CH3:32])[N:27]=6)[NH:23][N:22]=5)[CH2:18]4)=[CH:12][CH:11]=3)[C:7]([C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)=[CH:6][N:5]2[CH:39]=1.[Br:40]N1C(=O)CCC1=O>C(Cl)(Cl)Cl>[Br:40][C:39]1[N:5]2[CH:6]=[C:7]([C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[C:8]([C:10]3[CH:15]=[CH:14][C:13]([CH2:16][N:17]4[CH2:20][CH:19]([C:21]5[N:25]=[C:24]([C:26]6[CH:31]=[CH:30][CH:29]=[C:28]([CH3:32])[N:27]=6)[NH:23][N:22]=5)[CH2:18]4)=[CH:12][CH:11]=3)=[N:9][C:4]2=[N:3][C:2]=1[CH3:1]