Acetic Acid → HCID 178482058, compound

Participants

Reaction Steps

237.8 mg (0.87 mmol) 2-(5-Azetidine-3-yl-[1,2,4]triazole-3-yl)-pyridine×2HCl are dissolved in 6.8 mL NMP. 0.24 mL (1.74 mmol) triethylamine are added and the reaction mixture is stirred for one hour. 270 mg (0.79 mmol) 4-(2-Methyl-5-methylamino-6-phenyl-imidazo[1,2-a]pyrimidin-7-yl)-benzaldehyde and 0.11 mL (1.89 mmol) acetic acid are added. The reaction mixture is stirred for two days at room temperature. 401.1 mg (1.89 mmol) NaBH(OAc)3, are added in portions and the reaction mixture is stirred at room temperature for 9 days. After the usual work-up and purification by HPLC 29.6 mg (7.1%) of the desired title compound are obtained.

Provenance & Evidence