2-(5-Azetidine-3-yl-[1,2,4]triazole-3-yl)-pyridine → HCID 178498703, compound

HRID 1851316Notes

Reaction equation

HRID 1851316 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:6]=[C:7]2[N:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([CH:19]=O)=[CH:15][CH:14]=3)[C:10]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[CH:9][N:8]2[CH:27]=1)=[O:4].[NH:28]1[CH2:31][CH:30]([C:32]2[NH:36][N:35]=[C:34]([C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][N:38]=3)[N:33]=2)[CH2:29]1>>[CH3:1][O:2][C:3]([C:5]1[N:6]=[C:7]2[N:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([CH2:19][N:28]4[CH2:29][CH:30]([C:32]5[N:33]=[C:34]([C:37]6[CH:42]=[CH:41][CH:40]=[CH:39][N:38]=6)[NH:35][N:36]=5)[CH2:31]4)=[CH:15][CH:14]=3)[C:10]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[CH:9][N:8]2[CH:27]=1)=[O:4]

Participants

3

Reactant 2

HCID 687522842-(5-Azetidine-3-yl-[1,2,4]triazole-3-yl)-pyridineHCID 86703062HCID 86703062, compound

Product 1

HCID 178498703HCID 178498703, compoundYield 17.5%

Procedure

The title compound has been prepared in analogy to the aforementioned descriptions by reacting 500 mg (1.4 mmol) 7-(4-formylphenyl)-6-phenyl-imidazo[1,2-a]pyrimidine-2-carboxylic acid methyl ester with 383.6 mg (1.4 mmol) 2-(5-azetidine-3-yl-[1,2,4]triazole-3-yl)-pyridine×2HCl, yielding 132.6 mg (15.7%) of the desired product after purification.

Sources & evidence

ORD record
ord-0f228d8a0df040c592bdaa092ae0e6ae
Source dataset
uspto-grants-2015_02
Patent number
US08957064B2

Reaction notes

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