Tetrahydrofuran → HCID 57901841, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 1-(methoxymethyl)-7-[(methoxymethyl)(2-thienylsulfonyl)amino]-1H-indole-2-carboxylate (4.43 g), 8N aqueous sodium hydroxide solution (2.5 mL), tetrahydrofuran (10 mL) and ethanol (10 mL) was stirred at 60° C. for 1 hr. The reaction mixture was concentrated, and water was added to the residue. The mixture was acidified with 10% aqueous citric acid solution, and the resulting crystals were filtrated, washed with water, and dried to give the title compound (3.86 g, yield 93%) as colorless crystals. melting point 183-184° C.

Provenance & Evidence