Ammonia → HCID 57901741, compound

Participants

Reaction Steps

To a mixture of 1-(methoxymethyl)-7-[(methoxymethyl)(2-thienylsulfonyl)amino]-1H-indole-2-carboxylic acid (3.83 g), 1H-1,2,3-benzotriazol-1-ol (1.51 g) and N,N-dimethylformamide (30 mL) was added N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride (2.15 g) at room temperature, and the mixture was stirred for 20 min and 28% aqueous ammonia (3.4 mL) was added. The reaction mixture was stirred at room temperature for 3 hr, and water was added. The mixture was acidified with 10% aqueous citric acid solution, and the resulting crystals were filtrated, washed with water, and dried to give the title compound (3.67 g, yield 96%) as colorless crystals. melting point 203-204° C.

Provenance & Evidence