Tetrahydrofuran → HCID 136060813, compound

Participants

Reaction Steps

A mixture of 7-nitro-2-(1,2,4-thiadiazol-5-yl)-1H-indole (0.41 g), iron(III) chloride hexahydrate (33 mg), activated carbon (0.33 g), tetrahydrofuran (12 mL) and methanol (6 mL) was heated under reflux for 20 min. To the reaction mixture was added hydrazine monohydrate (0.50 g) over 10 min while heating under reflux. The reaction mixture was heated under reflux for 2 hr, filtrated, and the filtrate was concentrated. The resulting crystals were washed with water, and dried to give the title compound (0.35 g, yield 94%) as colorless crystals. melting point>223° C. (decomposition).

Provenance & Evidence