Dimethylformamide → HCID 57901810, compound

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A mixture of ethyl 4-fluoro-1-(methoxymethyl)-7-[(2-thienylsulfonyl)amino]-1H-indole-2-carboxylate (455 mg), methyl iodide (0.103 mL), potassium carbonate (183 mg) and N,N-dimethylformamide (10 mL) was stirred at room temperature for 18 hr. The reaction solution was diluted with ethyl acetate, washed with aqueous citric acid solution, water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give the title compound (0.45 g, yield 96%) as pale-pink crystals.

Provenance & Evidence