Lawesson's reagent → HCID 57901724, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-fluoro-1-(methoxymethyl)-7-[methyl(2-thienylsulfonyl)amino]-1H-indole-2-carboxamide (0.41 g), Lawesson's reagent (0.50 g) and tetrahydrofuran (40 mL) was stirred at 60° C. for 3 hr. The reaction solution was concentrated under reduced pressure, and the obtained residue was subjected to silica gel column chromatography (ethyl acetate:hexane=2:8-4:6) to give the title compound (0.25 g, yield 59%) as pale-yellow crystals.

Provenance & Evidence