Sodium Thiosulfate → HCID 57901786, compound

Participants

Reaction Steps

To a solution of [2-(1,3-thiazol-2-yl)-1H-indol-7-yl]methanol (0.610 g) in dichloromethane (50 mL) was added Dess-Martin oxidant (1.50 g), and the mixture was stirred at room temperature for 0.5 hr. the reaction mixture was added saturated aqueous sodium hydrogencarbonate solution and 1N aqueous sodium thiosulfate solution, and extracted with ethyl acetate. The extract was washed successively with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:hexane=5:95-50:50) to give the title compound (0.450 g, yield 74%) as pale-yellow crystals.

Provenance & Evidence