Dimethylformamide → HCID 57476062, compound

Participants

Reaction Steps

To a mixture of N-ethyl-N-{2-[5-(hydroxymethyl)-1,3-thiazol-2-yl]-1H-indol-7-yl}thiophene-2-sulfonamide (3.43 g), N,N-dimethylformamide (0.05 mL) and tetrahydrofuran (50 mL) was added thionyl chloride (1.56 g), and the mixture was stirred at room temperature overnight. The reaction mixture was diluted with ethyl acetate and saturated brine and washed with saturated brine. The organic layer was dried over magnesium sulfate and filtrated. The filtrate was concentrated, and the obtained solid was washed with ether-hexane (1:1) to give the title compound (3.27 g, yield 91%) as a pale-yellow solid.

Provenance & Evidence