2-Propanesulfonyl chloride → HCID 57901618, compound

Participants

Reaction Steps

To a mixture of 8-amino-2,3,4,9-tetrahydro-1H-carbazol-1-one (0.35 g) and pyridine (8 mL) was added propane-2-sulfonyl chloride (0.24 mL) at 0° C., and the mixture was stirred at room temperature for 2 hr. The reaction mixture was concentrated, 10% aqueous citric acid solution was added, and the resulting crystals were filtrated, washed with water and dried. The obtained crystals were subjected to silica gel column chromatography and the title compound (1.94 g, yield 19%) was obtained as colorless crystals from a fraction eluted with tetrahydrofuran-hexane (1:1, volume ratio). The crystals were recrystallized from ethyl acetate. melting point 267-268° C.

Provenance & Evidence