Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Citric Acid | HCID 311 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 2-Propanol, 1-amino-2-methyl- | HCID 95102 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 57476168 | HCID 57476168 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 57901596 | HCID 57901596 | 65% |
Reaction Steps
To a mixture of 7-[(2-thienylsulfonyl)amino]-1H-indole-2-carboxylic acid (1.00 g), 1-amino-2-methylpropan-2-ol (0.55 g), 1H-1,2,3-benzotriazol-1-ol (0.50 g) and N,N-dimethylformamide (15 mL) was added N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride (0.71 g) at 0° C., and the mixture was stirred at 60° C. overnight. Water was added to the reaction mixture and the mixture was acidified with 10% aqueous citric acid solution. The resulting crystals were filtrated, washed with water, and dried to give the title compound (0.77 g, yield 65%) as colorless crystals. melting point>234° C. (decomposition).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08957070B2 |
|---|
| Source dataset | uspto-grants-2015_02 |
|---|
| ORD ID | ord-d08ccf1257dc484a98e1be3a693e29a2 |
|---|
| Source note | uspto-grants-2015_02 |
|---|
