Triphenylphosphine Oxide → N-[2-(4,5-dihydro-1,3-thiazol-2-yl)-3-methyl-1H-indol-7-yl]thiophene-2-sulfonamide

Participants

Reaction Steps

To a solution of triphenylphosphine oxide (3.56 g) in dichloromethane (30 mL) was slowly added trifluoromethanesulfonic anhydride (1.10 mL) at 0° C. The mixture was stirred for 10 min, and 3-methyl-7-[(2-thienylsulfonyl)amino]-N-[2-(tritylthio)ethyl]-1H-indole-2-carboxamide (1.36 g) was added. The reaction mixture was stirred at room temperature for 3 hr and concentrated. Saturated aqueous sodium hydrogen carbonate was added, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with saturated brine, dried (MgSO4) and concentrated. The residue was subjected to silica gel column chromatography and the title compound (0.33 g, yield 41%) was obtained as colorless crystals from a fraction eluted with ethyl acetate-hexane (1:20→1:1, volume ratio). melting point 163-164° C.

Provenance & Evidence