Pyrrolidine → HCID 57901582, compound

Participants

Reaction Steps

To a mixture of 7-[(2-thienylsulfonyl)amino]-1H-indole-2-carboxylic acid (200 mg), pyrrolidine (65 μL), 1H-1,2,3-benzotriazol-1-ol (150 mg) and N,N-dimethylformamide (8 mL) was added N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride (190 mg) at 4° C., and the mixture was stirred at room temperature for 18 hr. The reaction mixture was diluted with ethyl acetate, washed with aqueous citric acid solution, aqueous sodium hydrogencarbonate solution and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained crystals were washed with ethyl acetate-hexane to give the title compound (210 mg, yield 90%) as pale-yellow needle crystals. melting point 248-249° C.

Provenance & Evidence