Dibenzylamine → HCID 57901610, compound

Participants

Reaction Steps

To a mixture of 7-[(2-thienylsulfonyl)amino]-1H-indole-2-carboxylic acid (44 mg), dibenzylamine (32 mg), 1H-1,2,3-benzotriazol-1-ol (31 mg) and N,N-dimethylformamide (8 mL) was added N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride (39 mg) at 4° C., and the mixture was stirred at room temperature for 18 hr. The reaction mixture was diluted with ethyl acetate, washed with aqueous citric acid solution, aqueous sodium hydrogencarbonate solution and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained crystals were washed with diethyl ether to give the title compound (53 mg, yield 78%) as pale-brown crystals. melting point 198-199° C.

Provenance & Evidence