Hydrochloric Acid → HCID 136060803, compound

Participants

Reaction Steps

N-(Methoxymethyl)-N-[1-(methoxymethyl)-2-(1-methyl-1H-1,2,4-triazol-5-yl)-1H-indol-7-yl]thiophene-2-sulfonamide (0.42 g), concentrated hydrochloride (1 mL) and methanol (6 mL) were heated under reflux for 6 hr. The reaction mixture was neutralized with aqueous sodium bicarbonate, and the resulting crystals were filtrated, washed with water, and dried to give the title compound (0.07 g, yield 20%) as colorless crystals. The crystals were recrystallized from ethyl acetate-hexane. melting point>271° C. (decomposition).

Provenance & Evidence