Tetrahydrofuran → HCID 57901850, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 7-[(2-methoxyethyl)(2-thienylsulfonyl)amino]-1H-indole-2-carboxylate (0.54 g), 2N aqueous sodium hydroxide solution (2.2 mL), tetrahydrofuran (4 mL) and methanol (4 mL) was stirred at 50° C. for 1 hr. The reaction mixture was concentrated, and water was added to the residue. The mixture was acidified with 10% aqueous citric acid solution, and the resulting crystals were filtrated, washed with water, and dried to give the title compound (0.46 g, yield 92%) as colorless crystals. melting point 216-217° C.

Provenance & Evidence