3-(Methylsulfonyl)benzenesulfonyl chloride → N-[2-(4,5-Dihydro-1,3-thiazol-2-yl)-1H-indol-7-yl]-3-(methylsulfonyl)-N-{[3-(methylsulfonyl)phenyl]sulfonyl}benzenesulfonamide

Participants

Reaction Steps

To a mixture of 2-(4,5-dihydro-1,3-thiazol-2-yl)-1H-indole-7-amine (100 mg) and pyridine (3 mL) was added 3-(methylsulfonyl)benzenesulfonyl chloride (140 mg) at 0° C., and the mixture was stirred at room temperature for 2 hr. The reaction mixture was concentrated, and the residue was subjected to silica gel column chromatography (ethyl acetate:hexane=1:1) to give the title compound (41 mg, yield 14%) as pale-yellow crystals. M+1=654.

Provenance & Evidence