3-(Trifluoromethyl)benzenesulfonyl chloride → HCID 57901670, compound

Participants

Reaction Steps

To a mixture of 2-(4,5-dihydro-1,3-thiazol-2-yl)-1H-indole-7-amine (100 mg) and pyridine (3 mL) was added 3-(trifluoromethyl)benzenesulfonyl chloride (140 mg) at 0° C., and the mixture was stirred at room temperature for 2 hr. The reaction mixture was concentrated, and the residue was subjected to silica gel column chromatography (ethyl acetate:hexane=1:1) to give the title compound (93 mg, yield 32%) as pale-yellow crystals. M+1=634.

Provenance & Evidence