Ammonia → HCID 57901869, compound

Participants

Reaction Steps

To a solution of 3-({methyl[2-(1,3-thiazol-2-yl)-1H-indol-7-yl]amino}sulfonyl)thiophene-2-carboxylic acid (100 mg), 1H-1,2,3-benzotriazol-1-ol (46 mg) and N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride (58 mg) in N,N-dimethylformamide (2 mL) was added 28% aqueous ammonia (1 mL), and the mixture was stirred at room temperature for 12 hr. To the reaction mixture was added 1N hydrochloric acid was added, and extracted with ethyl acetate. The ethyl acetate layer was washed with saturated brine, dried (MgSO4) and concentrated. The obtained residue was crystallized from diethyl ether-hexane to give the title compound (57 mg, yield 57%) as colorless crystals. melting point 269° C.

Provenance & Evidence