Triethylamine → HCID 57901710, compound

Participants

Reaction Steps

To a solution of 2-(chloromethyl)-N-methyl-N-[2-(1,3-thiazol-2-yl)-1H-indol-7-yl]thiophene-3-sulfonamide (110 mg) and triethylamine (150 μL) in tetrahydrofuran (5 mL) was added N-acetylpiperazine (33 mg). The reaction mixture was stirred at room temperature for 10 hr. The reaction mixture was concentrated, and the obtained residue was subjected to silica gel column chromatography (ethyl acetate:hexane=1:1) to give the title compound (108 mg, yield 81%) as pale-yellow crystals. melting point 242° C.

Provenance & Evidence