Sodium methanethiolate → HCID 57901718, compound

Participants

Reaction Steps

A solution of 2-(chloromethyl)-N-methyl-N-[2-(1,3-thiazol-2-yl)-1H-indol-7-yl]thiophene-3-sulfonamide (250 mg) and sodium methanethiolate (50 mg) in tetrahydrofuran (5 mL) was stirred at room temperature for 1 hr. The reaction mixture was concentrated, and the obtained crystals were collected by filtration. The crystals were washed with water and diethyl ether, and dried to give the title compound (256 mg, yield 99%) as pale-brown crystals. melting point 213° C.

Provenance & Evidence