Triethylamine → N-methyl-N-[2-(1,3-thiazol-2-yl)-1H-indol-7-yl]thiophene-2-carboxamide

Participants

Reaction Steps

To a solution of N-methyl-2-(1,3-thiazol-2-yl)-1H-indole-7-amine hydrochloride (200 mg) in tetrahydrofuran (3 mL) were added triethylamine (100 μL) and 2-thenoyl chloride (100 mg), and the mixture was stirred at room temperature for 1 hr. The reaction mixture was concentrated, and the obtained residue was subjected to silica gel column chromatography (ethyl acetate:hexane=1:3) to give the title compound (273 mg, yield 92%) as colorless crystals. melting point 250° C.

Provenance & Evidence