Dimethylsulphamoyl chloride → N,N,N'-Trimethyl-N'-[2-(1,3-thiazol-2-yl)-1H-indol-7-yl]sulfamide

Participants

Reaction Steps

To a solution of N-methyl-2-(1,3-thiazol-2-yl)-1H-indole-7-amine hydrochloride (100 mg) in pyridine (3 mL) was added dimethylsulfamoyl chloride (200 μL). The reaction mixture was stirred at room temperature for 3 hr. The reaction mixture was concentrated, and the obtained residue was subjected to silica gel column chromatography (ethyl acetate:hexane=1:1) to give. the title compound (88 mg, yield 69%) as yellow crystals. melting point 123° C.

Provenance & Evidence