Citric Acid → HCID 57901701, compound

Participants

Reaction Steps

A mixed solution of N-ethyl-N-[2-(5-formyl-1,3-thiazol-2-yl)-4,5-dimethyl-1H-indol-7-yl]thiophene-2-sulfonamide (85 mg), methanol (10 mL) and tetrahydrofuran (15 mL) was added sodium borohydride (10 mg) under ice-cooling, and the mixture was stirred at the same temperature for 2 hr. Aqueous citric acid solution was added to the reaction mixture, and the organic solvent was evaporated under reduced pressure. The obtained mixture was extracted with ethyl acetate, washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained crystals were washed with ethyl acetate-hexane to give the title compound (84 mg, yield 99%) as pale-yellow crystals, melting point 189-190° C.

Provenance & Evidence