Dimethylacetamide → HCID 57475966, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 7-[ethyl(2-thienylsulfonyl)amino]-1H-indole-2-carbothioamide (4.10 g), bromomalonaldehyde (3.55 g) and N,N-dimethylacetamide (30 mL) was stirred at 95° C. for 1.5 hr. To the reaction mixture was added water, and the obtained precipitate was dissolved in tetrahydrofuran (30 mL) and methanol (30 mL). After cooling in an ice bath, sodium borohydride (508 mg) was added, and the mixture was stirred at room temperature for 16 hr. The reaction mixture was concentrated and diluted with a mixture of ethyl acetate-tetrahydrofuran and washed successively with aqueous sodium bicarbonate and saturated brine. The organic layer was dried over magnesium sulfate and filtrated. The filtrate was concentrated, subjected to silica gel column chromatography, and eluted with an ethyl acetate-hexane (2:1) mixture to give the title compound (800 mg, yield 17%) as a solid.

Provenance & Evidence