Methylparaben → HCID 57901656, compound

Participants

Reaction Steps

N-ethyl-N-{2-[5-(hydroxymethyl)-1,3-thiazol-2-yl]-1H-indol-7-yl}thiophene-2-sulfonamide (420 mg) and methyl 4-hydroxybenzoate (153 mg) were dissolved in tetrahydrofuran (10 mL), and tri-tert-butylphosphine (263 mg) and 1,1′-(azodicarbonyl)dipiperidine (328 mg) were added. The reaction mixture was stirred at room temperature for 30 min. The reaction mixture was filtrated and the filtrate was concentrated. The residue was subjected to silica gel column chromatography and eluted with a mixture of ethyl acetate-hexane (1:1) to give the title compound (200 mg, yield 36%) as pale-yellow crystals. melting point 191° C.

Provenance & Evidence