Hydrochloric Acid → HCID 11978591, compound

Participants

Reaction Steps

Methyl 4-[(2-{7-[ethyl(2-thienylsulfonyl)amino]-1H-indol-2-yl}-1,3-thiazol-5-yl)methoxy]benzoate (98 mg), tetrahydrofuran (2 mL), methanol (2 mL) and 1N aqueous sodium hydroxide solution (2 mL) was stirred at 50° C. for 16 hr. The reaction mixture was acidified with 1N hydrochloride, diluted with ethyl acetate and washed with saturated brine. The organic layer was dried over magnesium sulfate and filtrated. The filtrate was concentrated, and the residue was subjected to silica gel column chromatography and recrystallized from an ethyl acetate-hexane (4:1) mixture to give the title compound (51 mg, yield 54%) as crystals. melting point 188° C.

Provenance & Evidence